TREACHER - COLLINS SYNDROME

 

RESEARCH CONSULTANT (by Dr. Francis Smith)

CRANIOFACIAL RESEARCH CONSULTING

 

Services offered:

--Experimental research consulting in craniofacial embryology, developmental biology, and 3-D imaging and image analysis to colleagues, as a visiting scientist or research consultant, on site.

--Short-term or long-term assistance, on site, in laboratory and experimental research procedures, as well as 3-D imaging (microCT, CT, etc.) and analysis of images for morphometrics, volumetrics, density measurement, and other purposes.

--Discussion and teaching/mentoring in such analyses to colleagues and/or their mentees.

--In-person, visiting at host’s university or institution, for such consultation, short- or long-term, domestically or internationally.

 

Experience: (refer to Francis Smith CV)

--Independent research consultant since 2019 to a colleague at University of Colorado Anschutz Medical Campus, School of Dental Medicine, Dr. Clifton Carey, in his studies of tooth density and mandibular bone density, by assisting and performing 3-D imaging by microCT and analysis of images for density analysis

--November 2017: visited Hospital for Rehabilitation of Craniofacial Anomalies in Bauru, Brazil, and assisted colleagues Dr. Ivy Trindade-Suedam and Dr. Inge Trindade in their study of upper airway obstruction in Treacher Collins. Performed analysis of CT images of patients with TCS for volumetric and morphological assessment of upper airway in TCS.

--Experience in craniofacial 3-D imaging and morphometrics, volumetrics, etc:

Dissertation project on hypoxia-induced craniofacial malformations in chick embryos, included 2-D morphometric analysis of images of hypoxic vs. normal embryos for abnormal craniofacial variation (UCSF, 2007-2012)

3-D imaging by microCT (for mouse and avian embryos and neonatal mouse skulls) and by CT (for human faces) and morphometric analysis of 3-D images for independent and collaborative projects in mouse craniofacial genetics and developmental biology, avian evolutionary trajectories, and clinical studies of craniofacial malformations (from clefts to syndromes) (University of Calgary, 2012-2015) and clinical projects that continued with collaborators after this period

Visiting research experience at Hospital for Rehabilitation of Craniofacial Anomalies in Bauru, Brazil, November 2017, assisting colleagues in volumetric and morphological assessment of upper airway obstruction in Treacher Collins syndrome via analysis of CT images by volumetrics and morphometrics

Independent research consulting to a University of Colorado Anschutz Medical Center colleague in 3-D imaging and analysis of dental samples for density, 2019-2020

 

Experience in craniofacial embryology (mouse and chick embryos), developmental biology, craniofacial biology, and genetics:

  • 2006-2007: King’s College London, UK: analysis of expression pattern of a novel gene in mouse embryos (2006) and analysis of genetic regulation of craniofacial myogenesis in chick embryos (2007)

  • 2007: UCSF, first PhD lab rotation: analysis of interaction between oral squamous cell carcinoma cells and surrounding extracellular matrix components

  • 2008: UCSF, second PhD lab rotation: assessment of hypoxia-induced craniofacial malformations in chick embryos (later evolved into dissertation project)

  • 2009: UCSF, third PhD lab rotation: examination of regulation of avian embryonic mandibular bone growth and development

  • 2009-2012: UCSF, PhD dissertation project: expanded assessment of morphological changes and molecular and cellular changes in response to hypoxia in chick embryos resulting in craniofacial malformations

  • 2015-2018: University of Colorado Anschutz Medical Campus, School of Dental Medicine, Department of Craniofacial Biology: postdoctoral training and experience in genomic and bioinformatic analysis of comparative expression of craniofacial genes among mouse embryonic craniofacial tissues

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Copyright 2020 -(Last Edition September 03, 2020 )